Comparative analysis of coal fatalities in Australia, South Africa, India, China and USA, 2006-2010

Coal mining (especially underground) is considered one of the most hazardous industries, and as a result considerable focus is applied to eliminating or mitigating hazards through careful mine planning, equipment selection and certification, and development of management systems and procedures. Regulatory agencies have developed in-house methods for reporting, classification and tracking of fatalities and other incidents according to the type of event, often including consideration of different hazard types. Unfortunately, direct comparison of mining safety statistics between countries is confounded by considerable differences in the way that individual countries classify specific fatalities or incidents. This paper presents a comparative analysis of coal mining fatality data in Australia, South Africa, India, China and the United States from 2006 to 2010. Individual classification definitions are compared between the five countries, and methods presented to normalise each country’s hazard definitions and reporting regimes around the RISKGATE framework of seventeen different priority unwanted events (or topics). Fatality data from individual countries is then re-classified according to the different RISKGATE topics, thereby enabling a comparative analysis between all five countries. This paper demonstrates the utility and value of a standard classification approach, and submits the RISKGATE framework as a model for classification that could be applied globally in coal mining. RISKGATE is the largest health and safety project ever funded by the Australian coal industry (http://www.riskgate.org) to build an industry body of knowledge to assist in managing common industry hazards. A comprehensive knowledge base has been captured for risk management of tyres, collisions, fires, isolation, strata underground, ground control open cut, explosions, explosives, manual tasks and slips/trips/falls. This has been extended to outburst, coal burst and bumps, interface displays and controls, tailings dams and inrush

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Ocular Drug Delivery

Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a significant challenge for delivery of a drug alone or in a dosage form, especially to the posterior segment. Identification of influx transporters on various ocular tissues and designing a transporter-targeted delivery of a parent drug has gathered momentum in recent years. Parallelly, colloidal dosage forms such as nanoparticles, nanomicelles, liposomes, and microemulsions have been widely explored to overcome various static and dynamic barriers. Novel drug delivery strategies such as bioadhesive gels and fibrin sealant-based approaches were developed to sustain drug levels at the target site. Designing noninvasive sustained drug delivery systems and exploring the feasibility of topical application to deliver drugs to the posterior segment may drastically improve drug delivery in the years to come. Current developments in the field of ophthalmic drug delivery promise a significant improvement in overcoming the challenges posed by various anterior and posterior segment diseases